Lyophilization is a process in which
water is removed from a frozen product and placed in vacuum which allows the
ice to directly convert into vapor. In this process ice is directly converted
in vapor phase without undergoing liquid phase. This process includes
three phases namely freezing, sublimation and desorption. Many products such as
biotechnologically derived, anti-infective and in vitro diagnostics are
manufactured through lyophilization process. Anti infective products include
semi synthetic penicillin, cephalosporin, erythromycin, doxycycline and
chloramphenicol which are produced through lyophilization. Biotechnologically
derived lyophilized products include methylprednisolone sodium and
hydrocortisone sodium succinate. Lyophilization is a crucial process in
detecting the presence of gram negative organism like Pseudomonas sp in a bulk
solution.
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The products which are to be
lyophilized are frozen at a temperature below than eutectic point. After
freezing, products are exposed to primary drying where it is converted in vapor
phase. It is important to hold drying temperature at least 4 to 5 degree below
than the eutectic point. Post sublimation phase desorption is performed where
products are exposed to secondary drying. In desorption stage the product is
released from the surface to set equilibrium between bulk phase and adsorbing
surface. The equipments required to perform this process includes drying
chamber, condenser vacuum system and process controller. The process
control instruments include, shelf, condenser temperature controller chamber
and condenser pressure controller.
Lyophilization is helpful in
manufacturing of those products which are unstable in solutions. In addition
these equipments are gaining importance in diagnostic segment since they are
able to detect the presence of microorganism in a bulk sample. Despite various
advantages, the market growth may anticipate a slow down due to various factors
such as vial contamination, increased handling and processing time, cost and
complexity of these equipments. Moreover moisture retention can also create
inappropriate biological products.
Some of the market players in this
industry segment are Apex Lyo, Baxter Biopharma Solutions, Federal Equipment
Co., Cambridge Scientific Products Ltd., Hospira Inc., and others.
This research report analyzes this
market depending on its market segments, major geographies, and current market
trends. Geographies analyzed under this research report include
- North America
- Asia Pacific
- Europe
- Rest of the World
This report provides comprehensive
analysis of
- Market growth drivers
- Factors limiting market growth
- Current market trends
- Market structure
- Market projections for upcoming years
This report is a complete study of
current trends in the market, industry growth drivers, and restraints. It
provides market projections for the coming years. It includes analysis of
recent developments in technology, Porter’s five force model analysis and
detailed profiles of top industry players. The report also includes a review of
micro and macro factors essential for the existing market players and new entrants
along with detailed value chain analysis.
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