Frontier Pharma: Pain - Identifying and Commercializing First-in-Class Innovation
The deal and co-development landscape of the pain therapies market has been meticulously assessed; critical changes in the licensing environment are also reviewed.
According to the findings of the report, the active pain pipeline is composed of as many as 796 products at all development stages. This gives evidence of the highly diverse array of molecular targets that are present in the active pain pipeline. The report identifies 122 first-in-class active-stage development programs. These programs account for about 13.6% of the entire pipeline, demonstrating the high degree of innovation that exists within the active pain pipeline.
The pain therapeutics market, on the other hand, presents a divergent picture. A paltry rate of innovation has been reported from the pain therapeutics market over the last decade because of the continued dominance of traditional active pharmaceutical ingredients.
Opioids dominate the segment for moderate-to-severe pain. But their potential for abuse has prompted pharmacos to reformulate opioids into abuse-resistant version. In the mild pain treatment segment, non-steroidal anti-inflammatory drugs (NSAID) enjoy a leading position. However, these drugs do not provide adequate treatment for certain types of chronic pain and neuropathic subtypes.
While most first-in-class innovation programs in the active pain pipeline still fall within the limits of early-stage development, the majority of these programs are centered on novel molecular targets for neuropathic pain – the most incapacitating and complex variety of chronic pain. Market players focusing on these drug classes could possibly alter the course of the pain therapies market.
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The pain deals ecosystem has been abuzz with several licensing and development agreements being signed over the last decade. The report finds that during this period, 112 co-development and 261 licensing agreements were signed. Despite investment dollars being channeled into the pain therapies market, there has been a conspicuous lack of deals and agreements for first-in-class products. Going forward, the unmet need for therapies to treat chronic pain and breakthroughs in research related to pathophysiologies of pain-subtypes will help foster more licensing and co-development partnerships.
Upcoming Reports:
(1) - Immunoassay Reagents Market - Global Industry Expert Opinions Analysis, Emerging Opportunities, Market Size, Share, Growth Drivers, Market Trends, Statistics And Forecast 2015 - 2020
An immunoassay is a biochemical test that measures the presence of concentration of macromolecules in the solution through the use of immunoglobulin or antibody. Immunoassay is available in different formats and variations in order to suite different requirements. Immunoassay usually involves multiple steps where reagents are added and washed away or separated at different steps of the assay. In some of the immunoassay methods, the reagents are mixed with the sample in order to measure the samples’ concentration. Immunoassay techniques are specially used to effectively analyze compounds having extremely low concentrations. Immunoassay reagents are widely employed in pharmaceuticals, clinical and environmental fields.
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Aggressive and consistent investment of the key market players in research and development is one of the major drivers for the growth of the overall immunoassay reagents market. Immunoassay also finds wide range of applications in detecting infectious diseases as well as diseases such as cancer and cardiac disorder among others. In addition, the introduction of innovative software tools coupled with increased consolidation of laboratories and hospitals to reduce maintenance cost and services has further boosted the demand for different test and assays. Thus, with the increasing demand for immunoassay in turn augments the overall growth of the reagents market. Lack of awareness, access and expertise required to conduct the immunoassay is expected to hamper the growth of the overall immunoassay reagent market. The immunoassay reagents utilized for thyroid testing where it is most widely consumed globally, while reagents used for conducting immunoassay for infectious diseases were the second largest consumed.
(2) - Tungsten Market - Global Industry Expert Opinions Analysis, Emerging Opportunities, Market Size, Share, Growth Drivers, Market Trends, Statistics And Forecast 2015 - 2020
Tungsten is a commercially important element is naturally found on Earth in form of chemical compounds. Tungsten’s important ore includes wolframite and scheelite. Tungsten is the second hardest material after diamond and has a very high melting point. Tungsten is normally mined from underground ores from scheelite or/and wolframite ores. Tungsten and its alloys have diverse commercial applications. Tungsten is primarily used for the production of cemented carbides (hard materials), used for shaping alloys, metals, plastics, wood composites, ceramics as well as construction and mining industry. Tungsten mill products are tungsten alloys or tungsten metal products such as electrodes, filaments, wires, rods, sheets, etc. Tungsten is also used as an important partner for high speed steels, tool steels, creep resistant tools and alloys and satellites.
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The use of tungsten for producing cemented carbide was the largest primary use of tungsten across the globe. The demand for tungsten is correlated to the general economic activity, since tungsten’s major applications are industrial applications. Cemented carbide was followed by mill products and steel/alloys respectively. Tungsten is also used in other chemical applications such as high temperature lubricants ceramics, scintillation detectors, etc. Tungsten carbides perform a crucial role in the field of engineering materials. Cemented carbides are made by cementing tungsten monocarbide grains in binder matrix of tough nickel or cobalt alloy by liquid phase sintering.
(3) - Nylon Fiber Market - Global Industry Expert Opinions Analysis, Emerging Opportunities, Market Size, Share, Growth Drivers, Market Trends, Statistics And Forecast 2015 - 2020
Nylon fibers belong to the group of synthetic polymers which are known as polyamides. Nylon was first produced in 1935 at DuPont’s research facility. Nylon is one of the most widely used polymers. Nylon is a thermoplastic silky material that was first used in the manufacturing of toothbrush bristles. Nylon fiber is a polyamide fiber that is manufactured using dicarboxylic acid and diamine. The two most common nylon fibers are nylon 6 (Polycaprolactam, a cyclic nylon intermediate) and nylon 66 (polyhexamethylene adiamide). Nylon fibers consists the chemical elements such as carbon, hydrogen, oxygen and nitrogen. Nylon fibers are the condensation copolymers that are manufactured by the reaction of equal parts of diamine and dicarboxylic acid.
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There are two most common methods used for manufacturing nylon for various fiber applications. One of the approaches includes the molecules having an acidic group reacting with molecules containing amine groups. The resulting nylon is generally named on the basis of the number of carbon atoms present between the two acid groups and the two amine groups. The reaction produces the monomers of intermediate molecular weight which are further reacted to form long polymer chains of nylon fibers. Nylon fibers are hard, strong and water resistant in nature. Nylon fibers find a wide range of applications in the automobile and textile industries.
(4) - Natural Adhesives & Sealants Market - Global Industry Expert Opinions Analysis, Emerging Opportunities, Market Size, Share, Growth Drivers, Market Trends, Statistics And Forecast 2015 - 2020
Adhesives are referred to as the binding material which is applied to different surfaces of material to prevent separation. Adhesives are generally available in synthetic and natural types and are further categorized as reactive and non-reactive forms. Sealants are widely available as a viscous material with very little or no flow for easy penetration of the substrate. Although the basic application of sealants and adhesives is almost the same however, sealants lack strength and elongation as compared to adhesives. Sealants are usually preferred if they are resistant, insoluble and provide appropriate adhesion.
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The global adhesives and sealants market is expected to be driven by the growing end-user industries such as construction and automobile industry. Adhesives and sealants are mainly used in construction industry to manufacture panel laminates, insulation, flooring, facades, and coatings among others. Moreover, the developing technology along with the wide range of sealants and adhesives application is expected to boost the overall growth of the market. In Latin America, cement is another major application segment of adhesives and sealants market in construction industry.
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